Chromatin regulation during C. elegans germline development.
نویسندگان
چکیده
Recent studies in Caenorhabditis elegans implicate PcG- and NuRD-like chromatin regulators in the establishment and maintenance of germline-soma distinctions. Somatic cells appear to utilize NuRD-related nucleosome-remodeling factors to overwrite germline-specific chromatin states that are specified through PcG-like activities. The germline, in turn, may rely on an asymmetrically inherited inhibitor to prevent chromatin reorganization that would otherwise erase pluripotency.
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عنوان ژورنال:
- Current opinion in genetics & development
دوره 13 5 شماره
صفحات -
تاریخ انتشار 2003